5
Authors
25
References
2021
Year Published
Abstract
Periodontitis is one of the most common oral diseases in the world. Periodontitis when diagnosed early have the better prognosis for the individual to save the tooth. Diagnostic markers are useful to indicate the presence of a disease process before excessive clinical damage occurs. One such main source of biomarker is gingival crevicular fluid. This review article deals with Gingival crevicular fluid (GCF) as a source of biomarkers for periodontal disease progression and severity which helps in diagnosis and prognosis in the field of Periodontology and also details about available various chairside diagnostic kits for the biomarkers.
KEYWORDS: Gingival Crevicular Fluid, Biomarkers, Periodontal Disease, Diagnostic Markers, Periodontitis
How to Cite
M, Indumathi., Priya, R.., Sudarsan, Sabitha., Mozhi, U.. and Kadhiresan, R.. Gingival Crevicular Fluid as a Biomarker of Periodontal Disease — A Narrative Review. J Indian Dent Assoc Madras. 2021;8(2). DOI: 10.37841/jidam_2021_V8_I2_04
M, ,, Indumathi& Priya, ,, R., Shanmuga& Sudarsan, ,, Sabitha& Mozhi, ,, U., Arun& Kadhiresan, ,, R. (2021). Gingival Crevicular Fluid as a Biomarker of Periodontal Disease — A Narrative Review. Journal of Indian Dental Association Madras, 8(2). https://doi.org/10.37841/jidam_2021_V8_I2_04
Indumathi M , R. Shanmuga Priya , Sabitha Sudarsan , U. Arun Mozhi , R. Kadhiresan . "Gingival Crevicular Fluid as a Biomarker of Periodontal Disease — A Narrative Review." Journal of Indian Dental Association Madras, vol. 8, no. 2, 2021. DOI: 10.37841/jidam_2021_V8_I2_04.
M Indumathi, Priya R., Sudarsan Sabitha, Mozhi U., Kadhiresan R.. Gingival Crevicular Fluid as a Biomarker of Periodontal Disease — A Narrative Review. J Indian Dent Assoc Madras. 2021;8(2). doi:10.37841/jidam_2021_V8_I2_04
Indumathi M , R. Shanmuga Priya , Sabitha Sudarsan , U. Arun Mozhi , R. Kadhiresan . "Gingival Crevicular Fluid as a Biomarker of Periodontal Disease — A Narrative Review." Journal of Indian Dental Association Madras 8, no. 2 (2021). https://doi.org/10.37841/jidam_2021_V8_I2_04.
References
- Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet. 2005;366:1809–1820.
- Kurtis B, Tüter G, Serdar M, et al. Evaluation of MMP-8 and MMP-9 in GCF in patients with chronic periodontitis. BMC Oral Health. 2015;15:63–70.
- Sahingur SE, Cohen RE. Analysis of host responses and risk for disease progression. Periodontol 2000. 2004;36:84–104.
- Lamster IB, Grbic JT. Diagnosis of periodontal disease based on analysis of host response. Periodontol 2000. 1995;7:83–99.
- Persson GR, DeRouen TA. Relationship between GCF aspartate aminotransferase and active tissue destruction. J Periodontal Res. 1990;25:81–87.
- Chambers DA, Imrey PB. A longitudinal study of aspartate aminotransferase in human gingival crevicular fluid. J Periodontal Res. 1991;26:65–74.
- Ishikawa I, Cimasoni G. Alkaline phosphatase in human gingival fluid and its relation to periodontitis. Arch Oral Biol. 1970;15:1401–1404.
- Baggiolini M, Dahinden CA. CC chemokines in allergic inflammation. Immunol Today. 1994;15:127–133.
- Lange DE, Schroeder HE. Structural localization of lysosomal enzymes in gingival sulcus cells. J Dent Res. 1972;51:272–278.
- Lamster IB, Oshrain RL. Correlation analysis for clinical and gingival crevicular fluid parameters. J Clin Periodontol. 1991;18:272–277.
- Ohlsson K, Olsson I. The neutral proteases of human granulocytes. Acta Odontol Scand. 1973;31:51–59.
- Kennett CN, Cox SW. Investigations into the cellular contribution to host tissue. J Periodontal Res. 1996;31:347–354.
- Tonacci A, Bazzano G, Bue AM, et al. Effects of initial periodontal therapy on crevicular fluid composition. J Periodontol. 2016;87:1341–1349.
- Del Fabbro M, Taschieri S, Colombo A, et al. Soft tissue healing and bone changes. J Oral Implantol. 2014;40:59–65.
- Umeda M, Miwa Z, Takeuchi Y, et al. The distribution of periodontopathic bacteria in periodontal lesions. J Periodontal Res. 2004;39:349–356.
- Buchmann R, Hasilik A. Amplified crevicular leukocyte activity in aggressive periodontal disease. J Dent Res. 2002;81:716–721.
- Nauseef WM. How human neutrophils kill and degrade microbes. Immunol Rev. 2007;219:88–102.
- Smith AJ, Wade W. The relationship between microbial factors and gingival crevicular fluid glycosaminoglycans. Arch Oral Biol. 1997;42:89–92.
- Akalin FA, Sengün D. Hydroxyproline and total protein levels in gingival fluid in patients with different forms of periodontitis. J Periodontol. 1993;64:323–329.
- Morrison PR, Edsall JT. Preparation and properties of serum and plasma proteins. J Am Chem Soc. 1948;70:3103–3108.
- Termine JD, Kleinman HK. Osteonectin, a bone-specific protein linking mineral to collagen. Cell. 1981;26:99–105.
- Nishijima Y, Yamaguchi M, Kojima T, et al. Levels of RANKL and OPG in gingival crevicular fluid during orthodontic tooth movement. Orthod Craniofac Res. 2006;9:63–70.
- Figueredo CM, Gustafsson A. Increased amounts of RANKL and OPG in GCF. J Clin Periodontol. 2018;45:1128–1135.
- Kaur S, White S, Bartold PM. Periodontal disease and systemic disease. Aust Dent J. 2015;60:301–308.
- Kinane DF, Stathopoulou PG, Papapanou PN. Periodontal diseases. Nat Rev Dis Primers. 2017;3:17038.