Soft tissue tumors are enormously vast and yet relatively undiscovered. Tumors and tumor like lesions of soft tissue continues to be a challenge to both the surgeons and pathologists due to their diversity in biological behavior and histogenesis. Soft tissue tumors are mesenchymal proliferations that occur in the extraskeletal, non-epithelial tissues of the body, excluding the viscera, coverings of the brain, and lymphoreticular system. Benign tumors are more common than malignant ones in ratio of 100:1. Hematoxylin & Eosin sections act as a useful diagnostic technique in the initial diagnosis of tumors. The goals of the review is to introduce the most common soft tissue entities of fibrous tissue origin and provide with a basic knowledge regarding the diversity of soft tissue tumors.
Key Words: Soft Tissue Tumors, Collagen, Fibroblasts, Histiocytes, Immunohistochemistry.
- Fletcher, Christopher DM, K. Krishnan Unni, and Fredrik Mertens, eds. Pathology and genetics of tumours of soft tissue and bone. Vol. 4. Iarc, 2002.
- Neville BW, Damm DD, Chi AC, Allen CM. Oral and maxillofacial pathology. 3rd Edition.
- Alawi F, Stratton D, Freedman PD. Solitary fibrous tumor of the oral soft tissues: a clinicopathologic and immunohistochemical study of 16 cases. The American journal of surgical pathology. 2001 Jul 1;25(7):900-10.
- Angiero F, Benedicenti S, Stefani M. Fibromatosis of the head and neck: morphological, immunohistochemical and clinical features. Anticancer research. 2008 May 1;28(3B):1725-32.
- Rajendran R. Shafer's textbook of oral pathology. 7th Edition.
- Soares AB, Lins LH, Mazedo AP, Pereira Neto JS, Vargas PA. Fibrosarcoma originating in the mandible. Medicina Oral, Patología Oral y Cirugía Bucal (Internet). 2006 Jun;11(3):243-6.
- Canelas MM, Cardoso JC, Andrade PF, Reis JP, Tellechea O. Fibrous histiocytomas: histopathologic review of 95 cases. Anais brasileiros de dermatologia. 2010 Apr;85(2):211-5.
- Al-Daraji W, Husain E, Zelger BG, Zelger B. A practical and comprehensive immunohistochemical approach to the diagnosis of superficial soft tissue tumors. International journal of clinical and experimental pathology. 2009;2(2):119.