Stromal Salivary Gland Neoplasms – A Review

Salivary gland mesenchymal tumors are rare and account for less than 5% of all salivary gland tumors. Stromal salivary gland tumors can be benign or sarcomatous .These can be further classified into tumors arising from blood and lymphatic vessels, nerves, fibrous tissue, adipose tissue, muscle and others. More than 90% of mesenchymal tumors arise in parotid gland and less than 10% involves submandibular or sublingual glands. These neoplasms of mesenchymal origin that involve or encroach on the major salivary glands are often difficult to diagnose. Since sarcomas are more aggressive or have poor prognosis, early diagnosis and treatment plan is mandatory for patient survival. This article hightlights the key features of the stromal salivary gland neoplasms.

1. Seifert G, Oehne H. [Mesenchymal (non-epithelial) salivary gland tumors. Analysis of 167 tumor cases of the salivary gland register]. Laryngologie, Rhinologie, Otologie. 1986 Sep;65(9):485-91.
2. G.I Ellis surgical pathology of the salivary glands 1991
3. Ponniah I, SureshKumar P, Karunakaran K, Shankar KA, Kumaran MG, Preeti LN. Hemangioma in minor salivary glands: real or illusion. Diagnostic pathology. 2006 Aug 17;1(1):1.
4. Bhatt CJ, Jagrit NN. Congenital hemangioma of parotid gland: A case report. Indian Journal of Radiology and Imaging. 2003 Feb 1;13(1):15.
5. McMenamin M, Quinn A, Barry H, Sleeman D, Wilson G, Toner M. Cavernous hemangioma in the submandibular gland masquerading as sialadenitis: case report. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 1997 Aug 31;84(2):146-8.
6. Berri T, Azizi S. Large cystic lymphangioma of the parotid gland in the adult. Egyptian Journal of Ear, Nose, Throat and Allied Sciences. 2014 Nov 30;15(3):259-61.
7. Putney FJ, Moran JJ, Thomas GK. Neurogenic tumors of the head and neck. The Laryngoscope. 1964 Aug 1;74(8):1037-59.
8. Bhaker P, Chatterjee D, Gochhait D, Radotra BD, Dey P. Schwannoma of the parotid gland: Diagnosis by fineneedle aspiration cytology. Journal of cytology/Indian Academy of Cytologists. 2014 Oct;31(4):196.
9. Kurtkaya-Yapicier O, Scheithauer BW, Woodruff JM. The pathobiologic spectrum of Schwannomas.2003;18:925–34.
10. Tati SY, Gole GN, Prabhala S, Gole SG. Plexiform neurofibroma of the submandibular salivary gland: a rare tumour. Indian Journal of Surgery. 2011 Jun 1;73(3):224-6.
11. Wolff, Marianne., Meningioma of the parotid gland: An insight into the pathogenesis of extracranial meningiomas. Human Pathology , 453 – 459
12. Deshmukh SD, Rokade VV, Pathak GS, Nemade SV, Ashturkar AV. Primary extra-cranial meningioma in the right submandibular region of an 18-year-old woman: a case report. Journal of medical case reports. 2011 Jul 2;5(1):1..
13. Hwang CS, Lee CH, Kim A, Shin N, Park WY, Park MG, Park DY. Nodular Fasciitis of the Parotid Gland, Masquerading as Pleomorphic Adenoma. Korean journal of pathology. 2014 Oct;48(5):366.
14. Khalkhali K, Azizi MR, Atighechi S. A fibrous histiocytoma of intermediate malignancy arisen from the parotid gland. Archives of Iranian medicine. 2007 Jan 1;10(1):100-3.
15. Desmoid tumor of the parotid gland rev stomatol chor maxillofac. 2006 dec 107(6);470-3
16. Bartley GB, Elizabeth A, Bradley MD, Garrity JA. Postdoctoral Training.Oral soft tissue myxoma, journal of indian academy of oral medicine and radiology, apr-jun 2012 (24)
17. Agaimy A, Ihrler S, Märkl B, Lell M, Zenk J, Hartmann A, Michal M, Skalova A. Lipomatous salivary gland tumors: a series of 31 cases spanning their morphologic spectrum with emphasis on sialolipoma and oncocytic lipoadenoma. The American journal of surgical pathology. 2013 Jan 1;37(1):128-37.
18. Qayyum S, Meacham R, Sebelik M, Zafar N. Sialolipoma of the parotid gland: case report with literature review comparing major and minor salivary gland sialolipomas. Journal of oral and maxillofacial pathology: JOMFP. 2013 Jan;17(1):95.
19. Ide F, Mishima K, Saito I. Angiomyoma in the submandibular gland: a rare location for a ubiquitous tumour. The Journal of Laryngology & Otology. 2003 Dec 1;117(12):1001-2.
20. Messa-Botero OA, Romero-Rojas AE, Olaya SI, Díaz-Pérez JA, Tapias-Vargas LF. Primary malignant solitary fibrous tumor/hemangiopericytoma of the parotid gland. Acta Otorrinolaringologica Espanola. 2011 Jun 30;62(3):242-5.
21. Fanburg-Smith JC, Furlong MA, Childers EL. Oral and salivary gland angiosarcoma: a clinicopathologic study of 29 cases. Modern pathology. 2003 Mar 1;16(3):263-71.
22. Benjamin E, Wells S, Fox H, Reeve NL, Knox F. Malignant fibrous histiocytomas of salivary glands. Journal of clinical pathology. 1982 Sep 1;35(9):946-53.
23. Al-Salihi KA, Samsudin AR. Malignant fibrous histiocytoma (MFH) of the mandible and submandibular salivary gland: report of a case. Oral Oncology Extra. 2004 Nov 30;40(10):123-5.
24. Goel A, Gupta SC, Gupta SC, Awasthi DN. Rhabdomyosarcoma of parotid gland. Indian Journal of Otolaryngology and Head & Neck Surgery. 1997 Oct 1;49(4):360-3.