4
Authors
9
References
2026
Year Published
Abstract
📥 Received: 01 Jan 2026
✅ Accepted: 25 Feb 2026
📤 Published: 31 Mar 2026
Osseointegration has traditionally been defined as a structural phenomenon dependent on the "bio-inert" properties of titanium. However, contemporary "osteoimmunology" redefines implant success as an immune-modulated outcome of the Foreign Body Reaction (FBR). This review examines the aseptic biological mechanisms where the innate immune system determines the fate of dental implants. It focuses on the sequential activation of the coagulation cascade, neutrophil recruitment, and the critical plasticity of macrophages (M1/M2 polarization). We discuss how the failure of these immune checkpoints leads to aseptic fibrous encapsulation rather than bone apposition, distinct from bacteria-induced peri-implantitis.
Keywords:
OsteoimmunologyMacrophage PolarizationOsseointegrationForeign Body Reaction (FBR)NeutrophilsTitanium
How to Cite
Vasudevan B, E JEP, Parameswari D, Hariharan A. The Influence Of Innate Immunity On Osseointegration: An Osteoimmunological Perspective. J Indian Dent Assoc Madras. 2026;13(1). DOI: 10.37841/jidam.2026.v13.i1.006
(Bharathi Vasudevan, Joel Edwin Paul E, Devi Parameswari, Annapoorni Hariharan). (2026). The Influence Of Innate Immunity On Osseointegration: An Osteoimmunological Perspective. Journal of Indian Dental Association Madras, 13(1). https://doi.org/10.37841/jidam.2026.v13.i1.006
Bharathi Vasudevan, et al. "The Influence Of Innate Immunity On Osseointegration: An Osteoimmunological Perspective." Journal of Indian Dental Association Madras, vol. 13, no. 1, 2026. DOI: 10.37841/jidam.2026.v13.i1.006.
Vasudevan B, E JEP, Parameswari D, Hariharan A. The Influence Of Innate Immunity On Osseointegration: An Osteoimmunological Perspective. J Indian Dent Assoc Madras. 2026;13(1). doi:10.37841/jidam.2026.v13.i1.006
Bharathi Vasudevan, Joel Edwin Paul E, Devi Parameswari, Annapoorni Hariharan. "The Influence Of Innate Immunity On Osseointegration: An Osteoimmunological Perspective." Journal of Indian Dental Association Madras 13, no. 1 (2026). https://doi.org/10.37841/jidam.2026.v13.i1.006.
References
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