Mechanical removal of plaque and calculus remains the cornerstone of periodontitis treatment, effectively disrupting the biofilm and reducing microbial load. However, achieving complete bacterial eradication and optimal periodontal healing is particularly challenging in smokers, as smoking is a well-established risk factor for periodontal disease progression and impaired healing. Among adjunctive treatments, hyaluronic acid (HA) gel has emerged as a promising local drug delivery option due to its biocompatibility, wound-healing properties, and potential to modulate periodontal inflammation. This case report highlights the role of HA gel in the management of periodontitis in a smoker, emphasizing its clinical benefits and therapeutic potential despite the challenges posed by tobacco use.
- Gontiya G, Galgali SR. Effect of hyaluronan on periodontitis: A clinical and histological study. J Indian Soc Periodontol. 2012 Apr;16(2):184-92.
- Shah K, Parikh H, Duseja S. Comparative evaluation of metformin gel and chlorhexidine gel as adjunct to scaling and root planning in the treatment of chronic periodontitis: a clinical study. Int J Dentistry Res. 2022;7(3):63-7.
- Shukla K, Pebbili KK. Role of hyaluronic acid during periodontal therapy & post-periodontal surgeries. Arch Dent Res. 2022;12(2):89-96.
- El-Emam EH, Ezzat OM, Almalahy HG. Efficacy of Locally Delivered Hyaluronic Acid Gel as an Adjunctive to Non-Surgical Management of Stage II or Stage III Periodontitis: A Randomized Controlled Trial with Microbiological Analysis. Egyptian Dental Journal. 2024 Jan 1;70(1):221-33.
- Vajawat M, Rao DPC, Kumar GSV, et al. Local delivery of hyaluronic acid as an adjunct to scaling and root planing in the treatment of chronic periodontitis in smokers and non-smokers: A clinical and microbiological study. J Indian Soc Periodontol. 2022 Sep-Oct;26(5):471-477.
- Amato M, Santonocito S, Polizzi A, et al. Local Delivery and Controlled Release Drugs Systems: A New Approach for the Clinical Treatment of Periodontitis Therapy. Pharmaceutics. 2023 Apr 21;15(4):1312.
- Shah SA, Vijayakar HN, Rodrigues SV, et al. To compare the effect of the local delivery of hyaluronan as an adjunct to scaling and root planing versus scaling and root planing alone in the treatment of chronic periodontitis. J Indian Soc Periodontol. 2016 Sep-Oct;20(5):549-556.