📚 JIDAM — Open Access Dental Journal|ISSN: 2582-0559|IDA Madras
JIDAM · Vol 11, Issue 1 · January–March 2024
Review Article

Nurturing Smiles: Mucositis and Xerostomia in Childhood Cancer

Rangeeth · Dr. Priyaa Rangeeth*
Department of Pediatric Dentistry, Thai Moogambigai Dental College and Hospital, Dr. MGR Educational and Research Institute, Deemed to be University, Maduravoyal, Chennai  |  *Corresponding Author: dr.rangeeth@yahoo.com
Vol 11 · Issue 1 · 2024 DOI: 10.37841/jidam.2024.v11.i1.001 🔓 Open Access 📅 Published: 30 January 2024
2
Authors
15
References
2024
Year Published
📝Abstract

Chemotherapy, a cornerstone treatment for childhood cancers, is associated with significant oral health complications due to its effects on rapidly dividing cells, including those in the oral mucosa. This article explores the impact of chemotherapy on oral health in children, focusing on conditions such as oral mucositis, xerostomia (dry mouth), and dental caries, which are common side effects of treatment. Chemotherapy-induced immunosuppression further increases the risk of oral infections, including fungal and bacterial infections. The article highlights the prevalence of these complications in pediatric oncology patients, emphasizing the importance of proactive oral care strategies to mitigate these effects. For xerostomia, salivary substitutes, chewing gum, and hydration are recommended to alleviate discomfort and prevent oral infections. The role of preventive oral hygiene, including gentle brushing with fluoride toothpaste and the use of soft-bristled toothbrushes, is stressed. Nutritional support also plays a crucial role in maintaining oral health, particularly for children with mucositis or xerostomia who may face difficulty eating. The article concludes by advocating for regular dental assessments, early intervention, and comprehensive care, including educational support for children and caregivers, to improve the quality of life for paediatric cancer patients undergoing chemotherapy. Early referral to specialized dental care is essential for optimal management of chemotherapy-induced oral health complications in this vulnerable population.

Keywords: Childhood Cancer, Chemotherapy, Oral Mucositis, Xerostomia, Cancer Pain, Quality of Life
Received: 04 October 2023  |  Accepted: 25 November 2023  |  Published: 30 January 2024
🔖How to Cite
Rangeeth, Priyaa Rangeeth. Nurturing Smiles: Mucositis and Xerostomia in Childhood Cancer. J Indian Dent Assoc Madras. 2024;11(1). DOI: 10.37841/jidam.2024.v11.i1.001
Rangeeth, & Rangeeth, P. (2024). Nurturing Smiles: Mucositis and Xerostomia in Childhood Cancer. Journal of Indian Dental Association Madras, 11(1). https://doi.org/10.37841/jidam.2024.v11.i1.001
Rangeeth, and Priyaa Rangeeth. "Nurturing Smiles: Mucositis and Xerostomia in Childhood Cancer." Journal of Indian Dental Association Madras, vol. 11, no. 1, 2024. DOI: 10.37841/jidam.2024.v11.i1.001.
Rangeeth, Rangeeth P. Nurturing Smiles: Mucositis and Xerostomia in Childhood Cancer. J Indian Dent Assoc Madras. 2024;11(1). doi:10.37841/jidam.2024.v11.i1.001
Rangeeth, and Priyaa Rangeeth. "Nurturing Smiles: Mucositis and Xerostomia in Childhood Cancer." Journal of Indian Dental Association Madras 11, no. 1 (2024). https://doi.org/10.37841/jidam.2024.v11.i1.001.
📚References
  1. Ritwik P. Dental Care for Patients With Childhood Cancers. Ochsner J. 2018;18(4):351–7.
  2. Ambati P, Galhotra V, Jondhale SN, Dolker T, Ravi M, Rathod P. Evaluation of oral complications in children undergoing chemotherapy: An observational study. J Indian Soc Pedod Prev Dent. 2024 Jul 1;42(3):184–9.
  3. Steliarova-Foucher E, Colombet M, Ries LAG, Moreno F, Dolya A, Bray F, et al. International incidence of childhood cancer, 2001–10: a population-based registry study. Lancet Oncol. 2017 Jun;18(6):719–31.
  4. Arora RS, Bagai P, Bhakta N. Estimated National and State Level Incidence of Childhood and Adolescent Cancer in India. Indian Pediatr. 2021 May 15;58(5):417–23.
  5. Black WC. Increasing Incidence of Childhood Primary Malignant Brain Tumors—Enigma or No-Brainer? JNCI J Natl Cancer Inst. 1998 Sep 2;90(17):1249–51.
  6. Pombo Lopes J, Rodrigues I, Machado V, Botelho J, Bandeira Lopes L. Chemotherapy and Radiotherapy Long-Term Adverse Effects on Oral Health of Childhood Cancer Survivors: A Systematic Review and Meta-Analysis. Cancers. 2023 Dec 25;16(1):110.
  7. Peterson DE, Bensadoun RJ, Roila F. Management of oral and gastrointestinal mucositis: ESMO Clinical Practice Guidelines. Ann Oncol. 2011 Sep;22:vi78–84.
  8. Toth BB, Martin JackW, Fleming TJ. Oral complications associated with cancer therapy: An M. D. Anderson Cancer Center experience. J Clin Periodontol. 1990 Aug;17(s1):508–15.
  9. Miller MM, Donald DV, Hagemann TM. Prevention and treatment of oral mucositis in children with cancer. J Pediatr Pharmacol Ther JPPT Off J PPAG. 2012 Oct;17(4):340–50.
  10. Mercadante V, Jensen SB, Smith DK, Bohlke K, Bauman J, Brennan MT, et al. Salivary Gland Hypofunction and/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO/MASCC/ASCO Guideline. J Clin Oncol. 2021 Sep 1;39(25):2825–43.
  11. Sreebny LM, Valdini A. Xerostomia. Part I: Relationship to other oral symptoms and salivary gland hypofunction. Oral Surg Oral Med Oral Pathol. 1988 Oct;66(4):451–8.
  12. Braguês R, Marvão MF, Correia P, Silva RM. Oral Mucositis Management in Children under Cancer Treatment: A Systematic Review. Cancers. 2024 Apr 18;16(8):1548.
  13. Stolze J, Teepen JC, Raber-Durlacher JE, Loonen JJ, Kok JL, Tissing WJE, et al. Prevalence and Risk Factors for Hyposalivation and Xerostomia in Childhood Cancer Survivors Following Different Treatment Modalities—A Dutch Childhood Cancer Survivor Study Late Effects 2 Clinical Study (DCCSS LATER 2). Cancers. 2022 Jul 11;14(14):3379.
  14. Mercadante V, Jensen SB, Smith DK, Bohlke K, Bauman J, Brennan MT, et al. Salivary Gland Hypofunction and/or Xerostomia Induced by Nonsurgical Cancer Therapies: ISOO/MASCC/ASCO Guideline. J Clin Oncol. 2021 Sep 1;39(25):2825–43.
  15. Choudhury P. Indian pediatrics and child survival. Indian Pediatr. 2007 Aug;44(8):567–8.